Adaptive facultative diet-induced thermogenesis in wild-type but not in UCP1-ablated mice
| Autor: | Erik Lindsund, Barbara Cannon, Jan Nedergaard, Gabriella von Essen |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Physiology Endocrinology Diabetes and Metabolism Adipose tissue Biology Diet induced thermogenesis 03 medical and health sciences Mice Oxygen Consumption Adipose Tissue Brown Physiology (medical) Internal medicine Brown adipose tissue medicine Animals Obesity Uncoupling Protein 1 Mice Knockout Wild type Calorimetry Indirect Thermogenesis medicine.disease Adaptation Physiological Thermogenin Diet Mice Inbred C57BL 030104 developmental biology medicine.anatomical_structure Endocrinology Metabolic control analysis Body Composition Energy Metabolism |
| Zdroj: | American journal of physiology. Endocrinology and metabolism. 313(5) |
| ISSN: | 1522-1555 |
| Popis: | The significance of diet-induced thermogenesis (DIT) for metabolic control is still debated. Although obesogenic diets recruit UCP1 and adrenergically inducible thermogenesis, and although the absence of UCP1 may promote the development of obesity, no actual UCP1-related thermogenesis identifiable as diet-induced thermogenesis has to date been unambiguously demonstrated. Examining mice living at thermoneutrality, we have identified a process of facultative (directly elicited by acute eating), adaptive (magnitude develops over weeks on an obesogenic diet), and fully UCP1-dependent thermogenesis. We found no evidence for UCP1-independent diet-induced thermogenesis. The thermogenesis was proportional to the total amount of UCP1 protein in brown adipose tissue and was not dependent on any contribution of UCP1 in brite/beige adipose tissue, since no UCP1 protein was found there under these conditions. Total UCP1 protein amount developed proportionally to total body fat content. The physiological messenger linking obesity level and acute eating to increased thermogenesis is not known. Thus UCP1-dependent diet-induced thermogenesis limits obesity development during exposure to obesogenic diets but does not prevent obesity as such. |
| Databáze: | OpenAIRE |
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