Characterizing the autonomic neural connections between the abdominal aortic and superior hypogastric plexuses: A multimodal neuroanatomical study
| Autor: | Adam M.R. Groh, Justin Lamont, Nagalingam Rajakumar, Jacob Fanous, Cleusa V.R. de Oliveira, Nicholas Power, Tyler S. Beveridge |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Retrograde ejaculation Inferior mesenteric ganglion Swine Pelvis medicine.nerve 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Superior hypogastric plexus Animals Humans Medicine Plexus Ganglia Sympathetic Hypogastric Plexus Endocrine and Autonomic Systems business.industry Splanchnic Nerves Anatomy medicine.disease Ganglion Neuronal tracing Neuroanatomy Neck of urinary bladder medicine.anatomical_structure Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Autonomic Neuroscience. 232:102785 |
| ISSN: | 1566-0702 |
| DOI: | 10.1016/j.autneu.2021.102785 |
| Popis: | The aortic plexus serves as the primary gateway for sympathetic fibers innervating the pelvic viscera. Damage to this plexus and/or its associated branches can lead to an assortment of neurogenic complications such as bladder dysregulation or retrograde ejaculation. The neuroanatomy of this autonomic plexus has only recently been clarified in humans; as such, the precise function of its constituent fibers is still not clear. Further study into the functional neuroanatomy of the aortic plexus could help refine nerve-sparing surgical procedures that risk debilitating neurogenic complications, while also advancing understanding of peripheral sympathetic circuitry. To this end, the current study employed an in vivo electrostimulation paradigm in a porcine model, in combination with lipophilic neuronal tracing experiments in fixed, post-mortem human tissues, to further characterize the functional neuroanatomy of the aortic plexus. Electrostimulation results demonstrated that caudal lumbar splanchnic nerves provide primary control over the porcine bladder neck in comparison to other constituent fibers within the aortic plexus. Ex vivo human data revealed that the prehypogastric ganglion contains a significant number of neurons projecting to the superior hypogastric plexus, and that these neurons are arranged in a topographic manner within the ganglion. Altogether, these findings suggest that a pivotal sympathetic pathway mediating bladder neck contraction courses through the caudal lumbar splanchnic nerves, prehypogastric and inferior mesenteric ganglia and superior hypogastric plexus. |
| Databáze: | OpenAIRE |
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