Structural studies of PNP from Toxoplasma gondii
| Autor: | Luiz Augusto Basso, Diógenes Santiago Santos, Ana Luiza Vivan, Walter Filgueira de Azevedo, Rafael Andrade Caceres |
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| Rok vydání: | 2009 |
| Předmět: |
Models
Molecular Molecular model Protein Conformation Clinical Biochemistry Population Molecular Sequence Data Biomedical Engineering Purine nucleoside phosphorylase Health Informatics Health Information Management parasitic diseases medicine Animals heterocyclic compounds Amino Acid Sequence education education.field_of_study Binding Sites biology Chemistry Rational design Toxoplasma gondii Plasmodium falciparum biology.organism_classification medicine.disease Virology Toxoplasmosis Purine-Nucleoside Phosphorylase Purine binding Sequence Alignment Toxoplasma |
| Zdroj: | International journal of bioinformatics research and applications. 5(2) |
| ISSN: | 1744-5485 |
| Popis: | Toxoplasmosis is a chronic infection that affects approximately 30% of the human population and is caused by Toxoplasma gondii. Determination of the three dimensional structure of PNP from T. gondii could provide new insights into the purine binding site and sub-strate binding, and could be used for future rational design of new drugs against toxoplasmosis. This work describes the molecular model for three dimensional structure of PNP from T.gondii using, as a template, PNP from Plasmodium falciparum. Molecular dynamics showed that this model is stable during a trajectory of 3 ns. |
| Databáze: | OpenAIRE |
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