Role of adiponectin and other inflammatory biomarkers in COPD patients
| Autor: | Hoda A. Ibraheem, Nagat Ali Mohamed, M. Amany Fawzy, Doaa Mostafa Gad, Reda Elgamry |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
lcsh:RC705-779
COPD Exacerbation Adiponectin biology business.industry Interleukin-6 Interleukin-8 Inflammation lcsh:Diseases of the respiratory system medicine.disease Cachexia respiratory tract diseases Tumor necrosis factor-α Immunology medicine biology.protein Biomarker (medicine) Tumor necrosis factor alpha medicine.symptom business Interleukin 6 hormones hormone substitutes and hormone antagonists |
| Zdroj: | Egyptian Journal of Chest Disease and Tuberculosis, Vol 62, Iss 1, Pp 45-50 (2013) |
| ISSN: | 0422-7638 |
| Popis: | Background: Adiponectin (APN) is a secretory protein synthesized by adipocytes and plays a potential role in regulating the inflammatory response by many of autocrine or paracrine. The mechanism of APN participation in the inflammation of COPD remains unknown. So, we investigated serum and induced sputum adiponectin as a biomarker of systemic inflammatory response and to find its relation with other inflammatory biomarkers like, IL-8, IL-6 and TNF-α. The aim of the work was also to find out its role in the pathogenesis of cachexia in COPD patients. Patients and methods: The study included 80 subjects including 60 COPD patients (20 stable and 40 exacerbated) and 20 age and sex-matched healthy control subjects. The adiponectin, interleukin-8, interleukin-6 and tumor necrosis factor-alpha levels were measured in serum, induced sputum by enzyme-linked immunosorbent assay. Serum CRP level was measured using the nephelometric method. Body mass index (BMI) was estimated for COPD patients and its relation to the inflammatory biomarkers was studied. Results: Adiponectin levels in COPD patients were significantly higher than those in control subjects (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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