Nutritional Interventions to Improve Clinical Outcomes in Ovarian Cancer: A Systematic Review of Randomized Controlled Trials
| Autor: | Marco Cintoni, Pauline Raoul, Giovanni Scambia, Emanuele Rinninella, Maria Cristina Mele, Giuseppe Scaletta, Giacinto Abele Donato Miggiano, Anna Fagotti, Antonio Gasbarrini, L. Quagliozzi |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
diet
nutrition therapy nutritional support ovarian cancer personalised medicine randomized controlled trials medicine.medical_specialty MEDLINE Psychological intervention Nutritional Status lcsh:TX341-641 Review law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial Risk Factors law medicine Humans 030212 general & internal medicine Medical nutrition therapy Risk factor Intensive care medicine Prospective cohort study Randomized Controlled Trials as Topic Ovarian Neoplasms Nutrition and Dietetics business.industry Malnutrition Cancer medicine.disease Treatment Outcome Settore MED/40 - GINECOLOGIA E OSTETRICIA 030220 oncology & carcinogenesis Inclusion and exclusion criteria Female business lcsh:Nutrition. Foods and food supply Food Science |
| Zdroj: | Nutrients, Vol 11, Iss 6, p 1404 (2019) Nutrients |
| ISSN: | 2072-6643 |
| Popis: | Among all gynaecological neoplasms, ovarian cancer has the highest rate of disease-related malnutrition, representing an important risk factor of postoperative mortality and morbidity. Hence, the importance of finding effective nutritional interventions is crucial to improve ovarian cancer patient’s well-being and survival. This systematic review of randomized controlled trials (RCTs) aims at assessing the effects of nutritional interventions on clinical outcomes such as overall survival, progression-free survival, length of hospital stay (LOS), complications following surgery and/or chemotherapy in ovarian cancer patients. Three electronic bibliographic databases (MEDLINE, Web of Science, and Cochrane Central Register of Controlled Trials) were used to conduct a systematic literature search based on fixed inclusion and exclusion criteria, until December 2018. A total of 14 studies were identified. Several early postoperative feeding interventions studies (n = 8) were retrieved mainly demonstrating a reduction in LOS and an ameliorated intestinal recovery after surgery. Moreover, innovative nutritional approaches such as chewing gum intervention (n = 1), coffee consumption (n = 1), ketogenic diet intervention (n = 2) or fruit and vegetable juice concentrate supplementation diet (n = 1) and short-term fasting (n = 1) have been shown as valid and well-tolerated nutritional strategies improving clinical outcomes. However, despite an acceptable number of prospective trials, there is still a lack of homogeneous and robust endpoints. In particular, there is an urgent need of RCTs evaluating overall survival and progression-free survival during ovarian oncology treatments. Further high-quality studies are warranted, especially prospective studies and large RCTs, with more homogeneous types of intervention and clinical outcomes, including a more specific sampling of ovarian cancer women, to identify appropriate and effective nutritional strategies for this cancer, which is at high risk of malnutrition. |
| Databáze: | OpenAIRE |
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