Possible recombination and gene adaptation exchanges among clinical echovirus strains: crossing the temporal and topological barriers
| Autor: | Panayotis Markoulatos, Evaggelos Dedepsidis, Anastassia Pratti, Z. Kyriakopoulou, Eugenia Bolanaki, Christine Kottaridi |
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| Rok vydání: | 2007 |
| Předmět: |
Microbiology (medical)
Serotype Echovirus viruses Molecular Sequence Data Sequence Homology Echovirus Infections Viral Nonstructural Proteins Biology medicine.disease_cause Genome Feces Viral Proteins Phylogenetics medicine Humans Gene Phylogeny Recombination Genetic Genetics Strain (biology) virus diseases DNA-Directed RNA Polymerases Sequence Analysis DNA General Medicine Enterovirus B Human Infectious Diseases Enterovirus RNA Helicases Recombination |
| Zdroj: | Diagnostic Microbiology and Infectious Disease. 58:407-412 |
| ISSN: | 0732-8893 |
| DOI: | 10.1016/j.diagmicrobio.2007.03.007 |
| Popis: | Six echovirus strains belonging to serotypes echovirus 6, 13, and 30 were investigated in the present work by sequencing of the whole 2C gene and about 560 nt of the 5' part of 3-dimensional genomic region. Four of the 6 echovirus strains were epidemics, whereas 2 were from sporadic cases. The whole procedure was carried out by using nucleotide distance matrices and phylogeny software. The sequences obtained strengthen the observation that recent echovirus isolates differ significantly from prototype strains in the downstream regions of the genome and provides further evidence that nonstructural enterovirus genes are ubiquitous and may combine freely adapting genomic sequences that are not restricted from the place of isolates' origin. For diagnostic purposes, particular emphasis is given on the utility of sequencing downstream genes and comparison of them with corresponding genomic regions from enteroviral strains that circulated all over the world. |
| Databáze: | OpenAIRE |
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