Augmentation of recombinant CH50 polypeptide on the function of macrophages of mice during chemotherapy
| Autor: | H Zhang, G Zhang, D Li, Zong-chen Feng, H Cao |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Cytotoxicity
Immunologic Cyclophosphamide medicine.medical_treatment Intraperitoneal injection Melanoma Experimental Abdominal cavity law.invention Mice Random Allocation Adjuvants Immunologic law Management of Technology and Innovation Antineoplastic Combined Chemotherapy Protocols medicine Splenocyte Animals Cytotoxicity Chemotherapy biology business.industry Recombinant Proteins Fibronectins Fibronectin medicine.anatomical_structure Immunology Macrophages Peritoneal biology.protein Recombinant DNA Cancer research business medicine.drug |
| Zdroj: | Journal of Tongji Medical University. 20:97-99 |
| ISSN: | 0257-716X |
| DOI: | 10.1007/bf02887040 |
| Popis: | The immunosuppressive model of mice was made by intraperitoneal injection of cyclophosphamide. The effect of CH50, a recombinant polypeptide of human fibronectin, on macrophages of mice was observed. The results showed that continuous intraperitoneal injection of CH50 could prevent the reduction of the number of monocytes in periphery blood and abdominal cavity by chemotherapeutic agents, enhance the metabolic activity and cytotoxicity of macrophages and augment the proliferation of splenocytes. The results suggested that CH50 is a product which could be used to improve the efficacy of chemotherapy of tumors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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