Respiratory syncytial and influenza viruses in children under 2 years old with severe acute respiratory infection (SARI) in Maputo, 2015

Autor: Sandra Mavale, Tufária Mussá, Orvalho Augusto, Afonso Nacoto, Eduardo Samo Gudo, Loira Machalele, Neuza Nguenha, Josina Chilundo, Mirela Pale, Félix Gundane, Délcio Muteto, Cynthia Semá-Baltazar, Germano Pires, Almiro Tivane
Rok vydání: 2017
Předmět:
Male
RNA viruses
Pediatrics
Viral Diseases
Influenza Viruses
Pulmonology
Antibiotics
lcsh:Medicine
Pathology and Laboratory Medicine
Geographical Locations
Families
0302 clinical medicine
Severe acute respiratory infection
Medicine and Health Sciences
Medicine
030212 general & internal medicine
Respiratory system
lcsh:Science
Children
Mozambique
Multidisciplinary
Respiratory distress
Antimicrobials
virus diseases
Drugs
Orthomyxoviridae
3. Good health
Infectious Diseases
Medical Microbiology
Child
Preschool
Population Surveillance
Viral Pathogens
Viruses
Bronchitis
Female
Pathogens
Pediatric Infections
Research Article
HIV infections
medicine.medical_specialty
medicine.drug_class
030231 tropical medicine
Respiratory Syncytial Virus Infections
Real-Time Polymerase Chain Reaction
Microbiology
Virus
03 medical and health sciences
Microbial Control
Influenza
Human
Humans
Medical prescription
Microbial Pathogens
Pharmacology
Biology and life sciences
business.industry
Public health
lcsh:R
Infant
Newborn
Organisms
Infant
medicine.disease
Influenza
Age Groups
Respiratory Syncytial Virus
Human
Respiratory Infections
People and Places
Africa
lcsh:Q
Population Groupings
business
Orthomyxoviruses
Zdroj: PLoS ONE
PLoS ONE, Vol 12, Iss 11, p e0186735 (2017)
ISSN: 1932-6203
Popis: Introduction Although respiratory syncytial virus (RSV) and influenza virus (influenza) infections are one of the leading causes of Severe Acute Respiratory Infections (SARI) and death in young children worldwide, little is known about the burden of these pathogens in Mozambique. Material and methods From January 2015 to January 2016, nasopharyngeal swabs from 450 children, aged ≤2 years, who had been admitted to the Pediatric Department of the Maputo Central Hospital (HCM) in Mozambique, suffering with SARI were enrolled and tested for influenza and RSV using a real-time PCR assay. Results Influenza and RSV were detected in 2.4% (11/450) and 26.7% (113/424) of the participants. Children with influenza were slightly older than those infected with RSV (10 months in influenza-infected children compared to 3 months in RSV-infected children); male children were predominant in both groups (63.6% versus 54.9% in children with influenza and RSV, respectively). There was a trend towards a higher frequency of influenza (72.7%) and RSV (93.8%) cases in the dry season. Bronchopneumonia, bronchitis and respiratory distress were the most common diagnoses at admission. Antibiotics were administered to 27,3% and 15,9% of the children with influenza and RSV, respectively. Two children, of whom, one was positive for RSV (aged 6 months) and another was positive for Influenza (aged 3 months) died; both were children of HIV seropositive mothers and had bronchopneumonia. Conclusions Our data demonstrated that RSV, and less frequently influenza, occurs in children with SARI in urban/sub-urban settings from southern Mozambique. The occurrence of deaths in small children suspected of being HIV-infected, suggests that particular attention should be given to this vulnerable population. Our data also provide evidence of antibiotics prescription in children with respiratory viral infection, which represents an important public health problem and calls for urgent interventions.
Databáze: OpenAIRE
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