Solifenacin objectively decreases urinary sensation in women with overactive bladder syndrome
| Autor: | Ramón A. Durazo-Arivzu, Lior Lowenstein, Edmond Sabo, Mary P. FitzGerald, Elizabeth R. Mueller, Kimberly Kenton, Linda Brubaker |
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| Rok vydání: | 2011 |
| Předmět: |
Solifenacin Succinate
Quinuclidines medicine.medical_specialty Urology Urinary system Urinary Bladder Sensation Muscarinic Antagonists urologic and male genital diseases Predictive Value of Tests Tetrahydroisoquinolines medicine Humans Aged Urinary bladder Solifenacin medicine.diagnostic_test Urinary Bladder Overactive business.industry Follow up studies Reproducibility of Results Cystometry Diagnostic Techniques Urological Equipment Design Syndrome Middle Aged Overactive bladder syndrome female genital diseases and pregnancy complications humanities Urodynamics Treatment Outcome medicine.anatomical_structure Nephrology Female business Follow-Up Studies medicine.drug |
| Zdroj: | International Urology and Nephrology. 44:425-429 |
| ISSN: | 1573-2584 0301-1623 |
| DOI: | 10.1007/s11255-011-0059-y |
| Popis: | To evaluate the test-retest reliability of a device that measures urinary sensation during cystometry, and to use that device to determine whether treatment of overactive bladder syndrome (OAB) with solifenacin is associated with a change in urinary sensation.Overall 15 women were recruited for this study, ten women with OAB and urodynamically demonstrated detrusor overactivity and five controls without OAB underwent filling cystometry twice with contemporaneous, continuous recording of urinary sensation. Women with OAB received solifenacin 10 mg daily during the weeks between testing. We compared the areas under the initial and repeat sensation-volume curves.While taking solifenacin, the maximum cystometric capacity increased from 329 ± 168 ml to 464 ± 123 ml (P0.002), and the area under the bladder volume-sensation curve decreased (P0.0001). Untreated controls did not exhibit these changes.We present psychometric data demonstrating improved bladder sensation during the treatment of OAB with solifenacin. If clinical correlations are confirmed by future study, such urinary sensation measures may prove useful as assessment, treatment predictor, or outcome measures in OAB research and/or clinical care. |
| Databáze: | OpenAIRE |
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