Force pattern of hypoxic myocardium applied to oxygenated muscle preparations: comparison with effects of regional ischemia on the contraction of non-ischemic myocardium
| Autor: | William H. Gaasch, Gen Shimizu, Antonio Carlos Cicogna, Allen W. Wiegner, Oscar H.L. Bing, Chester H. Conrad |
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| Rok vydání: | 1996 |
| Předmět: |
Male
medicine.medical_specialty Physiology Ischemia Cardiomyopathy Myocardial Ischemia Myocardial Reperfusion In Vitro Techniques Coronary artery disease Contractility Reperfusion therapy Physiology (medical) Internal medicine Medicine Animals Cardiac cycle business.industry Rats Inbred Strains Papillary Muscles medicine.disease Myocardial Contraction Rats Coronary occlusion Minicomputers Cardiology medicine.symptom Cardiology and Cardiovascular Medicine business Muscle contraction |
| Zdroj: | Cardiovascular research. 32(6) |
| ISSN: | 0008-6363 |
| Popis: | Objective: To examine the basis for local wall motion abnormalities commonly seen in patients with ischemic heart disease, computer-controlled isolated muscle studies were carried out. Methods: Force patterns of physiologically sequenced contractions (PSCs) from rat left ventricular muscle preparations under well-oxygenated conditions and during periods of hypoxia and reoxygenation were recorded and stored in a computer. Force patterns of hypoxic-reoxygenating and oxygenated myocardium were applied to oxygenated and hypoxic-reoxygenating myocardium, respectively. Results: Observed patterns of shortening and lengthening closely resemble those obtained from ischemic and non-ischemic myocardial segments using ultrasonic crystals in intact dog hearts during coronary occlusion and reperfusion, and are similar to findings reported in angiographic studies of humans with coronary artery disease. Conclusion: The current study, demonstrating motions of oxygenated isolated muscle preparations which are similar to those in perfused segments of intact hearts with regional ischemia, supports the concept that the multiple motions of both ischemic and non-ischemic segments seen in regional myocardial disease can be explained by interactions of strongly and weakly contracting muscle during the physiologic cardiac cycle. |
| Databáze: | OpenAIRE |
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