Synthetic indole Mannich bases: Their ability to modulate in vitro cellular immunity
| Autor: | M. Ahmed Mesaik, Shahnaz Perveen, Wolfgang Voelter, Khalid Mohammed Khan, Fazal Rahim, Ahmed Shukralla Khalid, Syed Moazzam Haider, Muhammad Taha, Samreen Soomro, Omer Mohamed Abdalla |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Cellular immunity Indoles T-Lymphocytes Context (language use) Nitric Oxide Biochemistry Nitric oxide Cell Line Mannich Bases chemistry.chemical_compound Immune system Drug Discovery Animals Humans Immunologic Factors Molecular Biology Cell Proliferation Indole test chemistry.chemical_classification Reactive oxygen species Immunity Cellular Chemistry Organic Chemistry Interleukin In vitro Cytokines Cattle Reactive Oxygen Species |
| Zdroj: | Bioorganic chemistry. 60 |
| ISSN: | 1090-2120 |
| Popis: | The synthetic indole Mannich bases 1-13 have been investigated for their ability to modulate immune responses measured in vitro. These activities were based on monitoring their affects on T-lymphocyte proliferation, reactive oxygen species (ROS), IL (interleukin)-2, IL-4, and nitric oxide production. Compound 5 was found to be the most potent immunomodulator in this context. Four of the synthesized compounds, 5, 11, 12, and 13, have significant potent inhibitory effects on T-cell proliferation, IL-4, and nitric oxide production. However, none of the thirteen indole compounds exerted any activity against ROS production. |
| Databáze: | OpenAIRE |
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