Cell-intrinsic requirement of Dscam1 isoform diversity for axon collateral formation
| Autor: | Olivier Urwyler, Haihuai He, Derya Ayaz, Dietmar Schmucker, Bing Yan, Yoshiaki Kise, Maria-Luise Erfurth, Akhila Parthasarthy, Dan Dascenco, Azadeh Izadifar |
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| Rok vydání: | 2014 |
| Předmět: |
Gene isoform
Cell physiology Cell Gene Dosage Biology Mechanotransduction Cellular 03 medical and health sciences 0302 clinical medicine RNA interference medicine Animals Drosophila Proteins Protein Isoforms Mechanotransduction Receptor Growth cone Alleles 030304 developmental biology 0303 health sciences Multidisciplinary Axons Cell biology Drosophila melanogaster medicine.anatomical_structure RNA Interference Cell Adhesion Molecules 030217 neurology & neurosurgery Sprouting |
| Zdroj: | Science (New York N.Y.) |
| ISSN: | 1095-9203 0036-8075 |
| Popis: | Wiring the developing insect brain Developmental brain wiring requires a complex set of cellular interactions often orchestrated by a large number of surface receptors. Thousands of Dscam1 receptor isoforms function as “surface tags” endowing neurons with unique molecular identities. These isoforms are important for neuronal self-recognition and dendrite self-avoidance. He et al. report that the diversity of Dscam1 isoforms is also essential for complex axonal branching of sensory neurons in developing fruit flies. Science , this issue p. 1182 |
| Databáze: | OpenAIRE |
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