Central nervous system involvement and psychiatric manifestations in systemic sclerosis (scleroderma): clinical and neurophysiological evaluation
| Autor: | Aki Hietaharju, M. Hietarinta, H. Frey, S. Jääskeläinen |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Psychosis medicine.medical_specialty genetic structures Encephalopathy Neurocognitive Disorders Neurological examination Scleroderma Optic neuropathy Scleroderma Localized Epilepsy Reference Values Reaction Time medicine Humans skin and connective tissue diseases Psychiatry Aged Cerebral Cortex Scleroderma Systemic integumentary system medicine.diagnostic_test business.industry Electroencephalography General Medicine Middle Aged medicine.disease Connective tissue disease Neurology Optic nerve Evoked Potentials Visual Brain Damage Chronic Female Neurology (clinical) Tomography X-Ray Computed business |
| Zdroj: | Acta Neurologica Scandinavica. 87:382-387 |
| ISSN: | 1600-0404 0001-6314 |
| DOI: | 10.1111/j.1600-0404.1993.tb04122.x |
| Popis: | We evaluated central nervous system and psychiatric involvement in a clinical sample of 32 patients with systemic sclerosis (SSc) (scleroderma). All patients underwent clinical neurological examination. Electroencephalography (EEG) and visual evoked potentials (VEPs) were also recorded. Prominent central nervous system (CNS) or psychiatric symptoms were present in 5 patients (16%), including encephalopathy, psychosis, anxiety disorder, grand mal seizures and transient ischemic attack. In addition, abnormal VEPs were recorded from 5/32 patients (16%), suggesting optic neuropathy. EEGs were mainly normal or showed only slight, nonspecific changes. Primary CNS involvement in scleroderma, however, could not be shown in any of the 5 cases with neuropsychiatric symptoms. Our results suggest that neuropsychiatric symptoms in SSc are, if not coincidental, indirectly caused by internal organ involvement of SSc or by possible overlapping connective tissue diseases. On the other hand, optic neuropathy might be a primary complication of SSc. |
| Databáze: | OpenAIRE |
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