Influence of high donor serum sodium levels on early postoperative graft function in human liver transplantation: Effect of correction of donor hypernatremia
| Autor: | Natalia Moras, Ernesto P. Molmenti, Ming-Che Lee, Atsushi Urakami, Jorge Gutierrez, Mauricio Gerardo, Forrest Dodson, Eishi Totsuka, John J. Fung, Tomohiro Ishii |
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| Rok vydání: | 1999 |
| Předmět: |
Adult
Graft Rejection Male medicine.medical_specialty medicine.medical_treatment Sodium Urology chemistry.chemical_element Liver transplantation Group A Graft function medicine Humans Prospective Studies Prospective cohort study Hypernatremia Hepatology business.industry Incidence Graft Survival Middle Aged Pennsylvania medicine.disease Tissue Donors Liver Transplantation Surgery Transplantation surgical procedures operative chemistry Female Graft survival business Liver Failure |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1074-3022 |
| DOI: | 10.1002/lt.500050510 |
| Popis: | Donor hypernatremia was reported to cause postoperative graft dysfunction in human orthotopic liver transplantation (OLT). However, the effects of the correction of donor hypernatremia before organ procurement have not been confirmed. The aim of this study is to determine whether donor hypernatremia is associated with early graft dysfunction after OLT and to determine the effect of the correction of donor hypernatremia. One hundred eighty-one consecutive OLTs performed between May 1997 and July 1998 were entered onto this study. The cases were divided into three groups according to the donor serum sodium concentration: group A, serum sodium of 155 mEq/L or less before organ procurement (n = 118); group B, peak sodium greater than 155 mEq/L and final sodium 155 mEq/L or less (n = 36); and group C, final sodium greater than 155 mEq/L (n = 27). Graft survival within 90 days after OLT and early postoperative graft function were analyzed. There were no significant differences in donor and recipient variables among the three groups. The frequencies of graft loss were 15 of 118 grafts (12.7%) in group A, 4 of 36 grafts (11.1%) in group B, and 9 of 27 grafts (33.3%; P |
| Databáze: | OpenAIRE |
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