Norovirus causing severe gastrointestinal disease following allogeneic hematopoietic stem cell transplantation: A retrospective analysis
| Autor: | Jonas Mattsson, Elda Sparrelid, Mats Remberger, Lisa Swartling, Per Ljungman, Mikael Sundin, Annika Tiveljung |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent medicine.medical_treatment Hematopoietic stem cell transplantation medicine.disease_cause Logistic regression Young Adult 03 medical and health sciences 0302 clinical medicine Immune system Internal medicine medicine Humans 030212 general & internal medicine Child Aged Caliciviridae Infections Retrospective Studies Transplantation Severe combined immunodeficiency business.industry Medical record Norovirus Hematopoietic Stem Cell Transplantation Infant Middle Aged medicine.disease Gastroenteritis Malnutrition Infectious Diseases Gastrointestinal disease Child Preschool Female 030211 gastroenterology & hepatology business |
| Zdroj: | Transplant Infectious Disease. 20:e12847 |
| ISSN: | 1398-2273 |
| Popis: | Background Norovirus (NV) can cause chronic and severe gastroenteritis with possible lethal outcome in immunocompromised patients. The knowledge of NV infections in allogeneic hematopoietic stem cell transplantation (HSCT) recipients is limited. The aim of this study was to clarify the clinical importance of NV in a large cohort of HSCT recipients. Methods All patients undergoing HSCT and diagnosed with NV at Karolinska University Hospital from 2006-2012 were included in the study (63 patients). Clinical data were collected from medical records, and statistics were performed using the logistic regression method. Results The majority of patients (70%) had short-term symptoms (≤14 days). However, 54% of all patients required admission or prolonged hospitalization owing to the infection. In 16% of the patients the symptoms were chronic (>30 days), and in all but one of these patients the clinical picture also was severe, with malnutrition requiring long-term TPN, or serious dehydration. Severe combined immune deficiency (SCID) diagnosis was associated with chronic symptoms of NV infection (OR 30.3, CI 2.5-368). Conclusion NV is an important pathogen in the HSCT setting, although the infection seems to be mild in most patients. Increased knowledge is needed to further identify risk factors for a severe course of NV infection in HSCT patients. |
| Databáze: | OpenAIRE |
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