Cancer-Associated Retinopathy during Treatment for Small-Cell Lung Carcinoma
| Autor: | Koji Kishi, Gen Sarashina, Kosuke Kashiwabara, Katsuyuki Kobayashi, Takeshi Matsuoka, Hisanaga Yagyu, Hiroyuki Nakamura |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
medicine.medical_specialty
Lung Neoplasms Paraneoplastic Syndromes Lipoproteins medicine.medical_treatment Visual Acuity Vision Low Nerve Tissue Proteins Gastroenterology Small-cell carcinoma Carboplatin chemistry.chemical_compound Retinal Diseases Adrenal Cortex Hormones Antigens Neoplasm Internal medicine Antineoplastic Combined Chemotherapy Protocols Hippocalcin Recoverin Internal Medicine medicine Carcinoma Humans Carcinoma Small Cell Eye Proteins Etoposide Aged Chemotherapy business.industry Calcium-Binding Proteins Combination chemotherapy General Medicine medicine.disease Surgery chemistry Female Small Cell Lung Carcinoma business Immunosuppressive Agents Retinopathy medicine.drug |
| Zdroj: | Internal Medicine. 38:597-601 |
| ISSN: | 1349-7235 0918-2918 |
| Popis: | A 70-year-old woman with small-cell lung carcinoma (c-T4N2M0) was treated by six courses of combination chemotherapy (carboplatin and etoposide). After two weeks, she complained of a sense of darkness and night blindness. A Western blot analysis showed that the patient's serum bound with the recombinant 23-kDa retinal cancer-associated retinopathy (CAR) antigen at 1:1,000 dilution. Her visual acuity became so poor that she could only recognise a hand motion at 50 cm despite treatment with corticosteroids and combination chemotherapy. The patient was diagnosed as having a rare type of CAR because CAR is usually found before the diagnosis of primary cancer. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|