Modification of oligodeoxynucleotides by on-column Suzuki cross-coupling reactions
| Autor: | Yogesh S. Sanghvi, Maria Ejlersen, Chenguang Lou, Yitzhak Tor, Jesper Wengel |
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| Rok vydání: | 2018 |
| Předmět: |
Oligodeoxyribonucleotides/chemistry
On column Idoxuridine/analogs & derivatives 010402 general chemistry 01 natural sciences Catalysis Coupling reaction chemistry.chemical_compound Idoxuridine Palladium/chemistry Materials Chemistry 010405 organic chemistry Oligonucleotide Boronic Acids/chemistry Metals and Alloys General Chemistry Boronic Acids Combinatorial chemistry 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials Monomer Oligodeoxyribonucleotides chemistry Ceramics and Composites Surface modification Palladium |
| Zdroj: | Ejlersen, M, Lou, C, Sanghvi, Y S, Tor, Y & Wengel, J 2018, ' Modification of oligodeoxynucleotides by on-column Suzuki cross-coupling reactions ', Chemical Communications, vol. 54, no. 57, pp. 8003-8006 . https://doi.org/10.1039/c8cc01360h |
| ISSN: | 1364-548X 1359-7345 |
| DOI: | 10.1039/c8cc01360h |
| Popis: | The on-column functionalization of oligodeoxynucleotides via base-free Suzuki cross-coupling reactions is reported herein. These cross-coupling reactions were carried out with various boronic acids and either full-length modified oligonucleotides containing one or more 2′-deoxy-5-iodouridine (5IdU) monomer(s) or on oligonucleotide fragments immediately after incorporation of 5IdU. Five different functionalities were coupled to oligonucleotides containing one or three attachment points. |
| Databáze: | OpenAIRE |
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