Stress-induced hyperthermia in mice: effects of flesinoxan on heart rate and body temperature
| Autor: | Theo H. Hijzen, Jan van der Gugten, J. Adriaan Bouwknecht, Robert A. A. Maes, Berend Olivier |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
Tachycardia Agonist Hyperthermia Fever medicine.drug_class Anxiolytic Piperazines Body Temperature Mice Heart Rate Stress Physiological Flesinoxan Heart rate Animals Telemetry Medicine 5-HT receptor Pharmacology business.industry Hypothermia medicine.disease Serotonin Receptor Agonists Anti-Anxiety Agents Anesthesia medicine.symptom business medicine.drug |
| Zdroj: | European Journal of Pharmacology. 400:59-66 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/s0014-2999(00)00387-3 |
| Popis: | Stress-induced hyperthermia in mice has predictive validity for anxiolytic properties of drugs. In this paradigm, 60 min after drug administration rectal temperature is measured, which causes hyperthermia of 1-1.5 degrees C (DeltaT) in about 10 min. Flesinoxan, a selective 5-HT(1A) receptor agonist with anxiolytic-like properties, causes hypothermia, which complicates interpretation of stress-induced hyperthermia. Therefore, we combined flesinoxan treatment and the stress paradigm with radiotelemetric measurement of body temperature and heart rate, which is also related to anxiety. Subjects were either undisturbed or injected with flesinoxan (0-0.1-0.3-1.0 and 3.0 mg/kg), with or without the stress paradigm. Flesinoxan (1.0 and 3.0 mg/kg) caused a relatively long-lasting hypothermia, but did not lower heart rate. The rectal temperature procedure caused hyperthermia and tachycardia. Flesinoxan reduced the stress-induced hyperthermia and the tachycardia evoked by the stress procedure. Continuous radiotelemetric measurement of heart rate, apart from body temperature, revealed that flesinoxan has anxiolytic-like properties in mice. |
| Databáze: | OpenAIRE |
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