The Road Map for Megakaryopoietic Lineage from Hematopoietic Stem/Progenitor Cells
Autor: | Shigeru Chiba, Naoki Kurita, Hidekazu Nishikii |
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Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
Cell type Myeloid Lineage (genetic) Biology Thrombopoiesis 03 medical and health sciences medicine Bone Marrow Stem Cells Animals Humans Cell Lineage lcsh:QH573-671 Progenitor cell Transcription factor Myeloid Progenitor Cells lcsh:R5-920 lcsh:Cytology Cell Biology General Medicine Cell biology Endothelial stem cell Haematopoiesis 030104 developmental biology medicine.anatomical_structure Hematopoietic Disorders Hematopoietic Stem/Progenitor Cells Immunology Perspective Stem cell lcsh:Medicine (General) Hematopoietic Regeneration Megakaryocytes Developmental Biology Perspectives |
Zdroj: | Stem Cells Translational Medicine Stem Cells Translational Medicine, Vol 6, Iss 8, Pp 1661-1665 (2017) |
ISSN: | 2157-6580 2157-6564 |
Popis: | Summary Megakaryocytes (Mgks) are terminally differentiated blood cells specified to produce platelets, whereas hematopoietic stem cells (HSCs) are the most undifferentiated blood cells that retain multipotency to produce all kinds of blood cells. As such, these two cell types reside at the bottom and the top of the hematopoietic hierarchy, respectively. In spite of this distance, they share several important cell surface molecules as well as transcription factors. In the conventional step-wise differentiation model, HSCs gradually lose their self-renewal capacity and differentiate into multipotent progenitors (MPPs), which is the first branch point of myeloid and lymphoid lineage. In this model, common myeloid progenitors can differentiate into bipotent Mgk/erythroid progenitors (MEPs), and MEPs eventually differentiate into unipotent mature Mgks. However, it has been recently reported that a subpopulation within the HSC and MPP compartments demonstrates an Mgk-biased differentiation potential. These reports imply that revisions to the HSC-to-Mgk differentiation pathway should be discussed. In this review, we summarize recent findings about Mgk differentiation from HSCs and discuss future directions in this research field. |
Databáze: | OpenAIRE |
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