The thymus hypocholesterolemic factor (TphF): a bovine thymic superoxide dismutase active on HMG-CoA reductase
| Autor: | Paolo Mondola, A. Belfiore, Santangelo F, Mariarosaria Santillo, L. Camardella |
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| Přispěvatelé: | Mondola, Paolo, Santillo, Mariarosaria, Belfiore, Anna, Camardella, L, Santangelo, Franco |
| Rok vydání: | 1993 |
| Předmět: |
Physiology
Sequence analysis Molecular Sequence Data Thymus Gland Biology Biochemistry Superoxide dismutase Animals Amino Acid Sequence Immunoelectrophoresis Molecular Biology chemistry.chemical_classification Sequence Homology Amino Acid Animal Superoxide Dismutase Protein primary structure Biological activity General Medicine Metabolism Amino acid Thymus Hormones Thymus Hormone Isoelectric point Enzyme chemistry biology.protein Cattle Electrophoresis Polyacrylamide Gel Immunoelectrophoresi Isoelectric Focusing Hydroxymethylglutaryl-CoA Reductase Inhibitors |
| Zdroj: | Comparative Biochemistry and Physiology Part B: Comparative Biochemistry. 104:193-199 |
| ISSN: | 0305-0491 |
| DOI: | 10.1016/0305-0491(93)90358-c |
| Popis: | 1. 1. This work describes the further biochemical characterization of a new calf thymus protein (TphF) and its primary structure. 2. 2. The amino acid sequences, obtained after sequence analysis of peptides derived from the endoproteinase Lys-C digestion, were subjected to a “Protein Data Bank Search” and were found to be identical with regions of bovine superoxide-dismutase (SOD). 3. 3. These data together with those showing the identical electrophoretic migration of SOD and TphF, their same isoelectric point and their immunoreactivity with anti-SOD antibodies, confirm the similarity of these two proteins. |
| Databáze: | OpenAIRE |
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