The renin angiotensin system in liver and lung: impact and therapeutic potential in organ fibrosis
| Autor: | Tarek Mohamed, Hanan Omar, Amal Abdul-Hafez, Bruce D. Uhal, Mohammed Shemis |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Chronic bronchitis Lung business.industry Interstitial lung disease respiratory system medicine.disease Cystic fibrosis Article respiratory tract diseases 03 medical and health sciences Idiopathic pulmonary fibrosis 030104 developmental biology medicine.anatomical_structure Fibrosis Pulmonary fibrosis medicine business Lung cancer |
| Zdroj: | Journal of Lung, Pulmonary & Respiratory Research. 5 |
| ISSN: | 2376-0060 |
| Popis: | Liver and lung fibrosis are two main organ diseases that are of particular importance in both Egypt and the US. Hepatitis C Virus "HCV" infection and idiopathic pulmonary fibrosis (IPF) are fibrotic diseases of the liver and lung respectively. The liver and lung are reported in literature to share many immune/inflammatory responses to damage through the lung-liver axis. Most importantly, HCV was shown to enhance the development of IPF and is considered one of the risk factors for IPF. The renin angiotensin system (RAS) plays a critical role in the fibrogenesis and inflammation damage of many organs including liver and lung. The relatively recently identified component of RAS, angiotensin converting enzyme-2 (ACE-2), has shown a promising therapeutic potential in models of liver and pulmonary fibrosis. This article reviews the role of RAS in organ fibrosis with focus on role of ACE-2 in fibrotic diseases of the liver and the lung. |
| Databáze: | OpenAIRE |
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