Evaluating the prognostic value and functional roles of transcription factor AP4 in colorectal cancer
| Autor: | Ma Jp, Siyu Xiao, Yang Jie, S. Cai, Xin-Hua Zhang, Jian‑Bo Xu, Yu‑Long He, Chuang‑Qi Chen |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cancer Research Colorectal cancer colorectal cancer Metastasis 03 medical and health sciences 0302 clinical medicine medicine metastasis neoplasms transcription factor AP4 Gene knockdown Oncogene business.industry Cancer Articles Cell cycle medicine.disease Molecular medicine digestive system diseases 030104 developmental biology cell proliferation Oncology 030220 oncology & carcinogenesis Cancer research Ectopic expression business |
| Zdroj: | Oncology Letters |
| ISSN: | 1792-1082 1792-1074 |
| Popis: | The basic helix-loop-helix transcription factor AP4 (TFAP4) gene serves an important function in the genesis and progression of tumors. However, few studies to date have defined the role of this gene in colorectal cancer (CRC). The aim of the present study was to assess the expression of TFAP4 in CRC and its impact on the prognosis of patients with CRC. In the present study, the expression of TFAP4 was detected in 30 matched pairs of fresh CRC tissues, 187 cases of clinical paraffin-embedded CRC tissues and CRC cell lines using the reverse transcriptase-quantitative polymerase chain reaction, immunohistochemistry or western blot analysis. Survival analysis was based on TFAP4 expression. The effects of TFAP4 on CRC cell function were investigated by ectopic expression or knockdown of TFAP4 in vitro. TFAP4 expression was revealed to be increased in human CRC tissues and cell lines. The overall survival (OS) time of patients with high TFAP4 expression was significantly decreased compared with patients with low TFAP4 expression (P |
| Databáze: | OpenAIRE |
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