Nicotinamide Deamidation by Microorganisms in Rat Stomach
| Autor: | Yoshinori Tanigawa, Toichi Ito, Makoto Shimoyama, Tsunesuke Tomoda, Iwao Ueda, Ryuzo Murashima |
|---|---|
| Rok vydání: | 1971 |
| Předmět: |
Male
Niacinamide Chromatography Paper Physiology and Metabolism medicine.disease_cause Flavobacterium Microbiology Enterococcus faecalis chemistry.chemical_compound Lactobacillus acidophilus Aminohydrolases Escherichia coli medicine Animals Deamidation Molecular Biology Bacteriological Techniques Carbon Isotopes biology Nicotinamide Stomach Nicotinic Acids Rats Inbred Strains Hydrogen-Ion Concentration NAD biology.organism_classification Rats Biochemistry chemistry Gastric Mucosa NAD+ kinase |
| Zdroj: | Journal of Bacteriology. 108:191-195 |
| ISSN: | 1098-5530 0021-9193 |
| DOI: | 10.1128/jb.108.1.191-195.1971 |
| Popis: | We have extended our investigation of nicotinamide deamidation in the stomach of conventional rats. The bacterial species in the pars preventricularis were identified as Flavobacterium peregrinum, Escherichia coli, Streptococcus faecalis , and Lactobacillus acidophilus , listed in order of decreasing deamidase activity. Nicotinamide- 7 - 14 C ingested into rat stomach was rapidly deamidated to nicotinic acid. These results contribute to the accumulated evidence that microorganisms present in the pars preventricularis of rat stomach are responsible for the deamidation of nicotinamide to nicotinic acid, a known precursor of mammalian pyridine nucleotides. |
| Databáze: | OpenAIRE |
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