Specific Immunotherapy with Neuraminidase-Modified Leukemic Cells: Experimental and Clinical Trials
| Autor: | James F. Holland, Julia P. Roboz, J. George Bekesi |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Oncology
medicine.medical_specialty medicine.medical_treatment Neuraminidase Antineoplastic Agents Lymphocyte Activation Mice Mice Inbred AKR Antigens Neoplasm In vivo Internal medicine Animals Humans Medicine Leukemia L1210 Skin Tests Clinical Trials as Topic Immunity Cellular Chemotherapy Leukemia Experimental biology business.industry Immunologic Tests Immunity General Medicine Immunotherapy medicine.disease Clinical trial Leukemia Leukemia Myeloid Mice Inbred DBA biology.protein Immunocompetence business |
| Zdroj: | Medical Clinics of North America. 61:1083-1100 |
| ISSN: | 0025-7125 |
| DOI: | 10.1016/s0025-7125(16)31283-4 |
| Popis: | The data presented establish the therapeutic effectiveness of immunotherapy with neuraminidase-treated allogeneic myeloblasts in combination with sustaining chemotherapy in patients with acute myelocytic leukemia. The in vivo and in vitro immunologic tests indicate normal immunocompetence in patients receiving immunotherapy versus control patients treated with chemotherapy alone. These findings correlate well with the improved duration of remission as the direct result of the immunotherapy. |
| Databáze: | OpenAIRE |
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