Alterations in the Gut Microbiota Associated with HIV-1 Infection
| Autor: | Catherine A. Lozupone, Sonia C. Flores, Andrew P. Fontenot, Rob Knight, Matthew J. Gebert, Thomas B. Campbell, Marcella Li, Brent E. Palmer, Derek J. Linderman |
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| Rok vydání: | 2013 |
| Předmět: |
Cancer Research
Human immunodeficiency virus (HIV) HIV Infections Gut flora medicine.disease_cause Feces RNA Ribosomal 16S 2.1 Biological and endogenous factors Aetiology 0303 health sciences Gastrointestinal tract biology Bacterial virus diseases Biota 3. Good health Infectious Diseases Medical Microbiology HIV/AIDS Infection Sequence Analysis DNA Bacterial 16S Immunology Molecular Sequence Data DNA Ribosomal digestive system Microbiology Article Bacterial genetics 03 medical and health sciences Immune system Virology Immunology and Microbiology(all) medicine Humans Molecular Biology Nutrition 030304 developmental biology Ribosomal Bacteria 030306 microbiology DNA Sequence Analysis DNA biology.organism_classification medicine.disease Gastrointestinal Tract RNA Dysbiosis Parasitology |
| Zdroj: | Cell host & microbe, vol 14, iss 3 |
| ISSN: | 1931-3128 |
| DOI: | 10.1016/j.chom.2013.08.006 |
| Popis: | SummaryUnderstanding gut microbiota alterations associated with HIV infection and factors that drive these alterations may help explain gut-linked diseases prevalent with HIV. 16S rRNA sequencing of feces from HIV-infected individuals revealed that HIV infection is associated with highly characteristic gut community changes, and antiretroviral therapy does not consistently restore the microbiota to an HIV-negative state. Despite the chronic gut inflammation characteristic of HIV infection, the associated microbiota showed limited similarity with other inflammatory states and instead showed increased, rather than decreased, diversity. Meta-analysis revealed that the microbiota of HIV-infected individuals in the U.S. was most similar to a Prevotella-rich community composition typically observed in healthy individuals in agrarian cultures of Malawi and Venezuela and related to that of U.S. individuals with carbohydrate-rich, protein- and fat-poor diets. By evaluating innate and adaptive immune responses to lysates from bacteria that differ with HIV, we explore the functional drivers of these compositional differences. |
| Databáze: | OpenAIRE |
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