Amikacin-induced acute kidney injury in mechanically ventilated critically ill patients with sepsis
| Autor: | Bişar Ergün, Fethiye Esenkaya, Murat Küçük, Mehmet Nuri Yakar, Özcan Uzun, Cihan Heybeli, Volkan Hanci, Begüm Ergan, Bilgin Cömert, Ali Necati Gökmen |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Journal of Chemotherapy. :1-9 |
| ISSN: | 1973-9478 1120-009X |
| DOI: | 10.1080/1120009x.2022.2153316 |
| Popis: | In this retrospective cohort study, we aimed to evaluate the incidence, risk factors and outcomes of amikacin-induced acute kidney injury (AKI) in critically ill patients with sepsis. A total of 311 patients were included in the study. Of them, 83 (26.7%) had amikacin-induced AKI. In model 1, the multivariable analysis demonstrated concurrent use of colistin (OR 25.51, 95%CI 6.99-93.05, p0.001), presence of septic shock during amikacin treatment (OR 4.22, 95%CI 1.76-10.11, p=0.001), and Charlson Comorbidity Index (OR 1.14, 95%CI 1.02-1.28, p=0.025) as factors independently associated with an increased risk of amikacin-induced AKI. In model 2, the multivariable analysis demonstrated concurrent use of at least one nephrotoxic agent (OR 1.95, 95%CI 1.10-3.45; p=0.022), presence of septic shock during amikacin treatment (OR 3.48, 95%CI 1.61-7.53; p=0.002), and Charlson Comorbidity Index (OR 1.12, 95%CI 1.01-1.26; p=0.037) as factors independently associated with an increased risk of amikacin-induced AKI. In conclusion, before amikacin administration, the risk of AKI should be considered, especially in patients with multiple complicated comorbid diseases, septic shock, and those receiving colistin therapy. |
| Databáze: | OpenAIRE |
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