Angiotensin-converting enzymes (ACE, ACE2) gene variants and COVID-19 outcome

Autor: Juan Gómez, Carlos López-Larrea, Marta E. Alvarez-Argüelles, Santiago Melón, Guillermo M. Albaiceta, Laura Amado-Rodríguez, Susana Rojo-Alba, Rebeca Lorca, Inés López-Alonso, Eliecer Coto, Ana I. Enriquez, Tamara Hermida, José Antonio Boga, Elías Cuesta-Llavona, Victoria Alvarez, Pablo Herrero, Marta García-Clemente
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Male
RFLP
restriction fragment length polymorphism
Genotyping Techniques
Bioinformatics
Pathogenesis
0302 clinical medicine
ACE
angiotensin converting enzyme
INDEL Mutation
Risk Factors
Genotype
Aged
80 and over
biology
Gene polymorphism
General Medicine
Middle Aged
030220 oncology & carcinogenesis
Ang
angiotensin
Hypertension
Female
Angiotensin-Converting Enzyme 2
Angiotensin converting enzyme
Coronavirus Infections
hormones
hormone substitutes
and hormone antagonists
Adult
Short Communication
Hypercholesterolemia
Pneumonia
Viral
Peptidyl-Dipeptidase A
Polymorphism
Single Nucleotide
RAAS
renin-angiotensin aldosterone system
03 medical and health sciences
Betacoronavirus
Young Adult
ICU
Intensive Care Unit
Renin–angiotensin system
Genetics
Humans
Gene
Pandemics
Genetic association
Aged
SARS-CoV-2
Case-control study
COVID-19
Angiotensin-converting enzyme
Covid-19
coronavirus disease 19
030104 developmental biology
Spain
Case-Control Studies
biology.protein
Zdroj: Gene
ISSN: 0378-1119
DOI: 10.1016/j.gene.2020.145102
Popis: Highlights • The Angiotensin system has been implicated in the pathogenesis of COVID-19. • Functional ACE/ACE2 polymorphisms might contribute to the outcome of COVID-19. • Severe COVID-19 was associated with hypertension, male gender, and ACE-DD genotype. • The ACE2 polymorphism was not associated with the disease outcome. • ACE2 showed no coding variants that could explain an increased risk of COVID-19.
The Angiotensin system is implicated in the pathogenesis of COVID-19. First, ACE2 is the cellular receptor for SARS-CoV-2, and expression of the ACE2 gene could regulate the individuaĺs susceptibility to infection. In addition, the balance between ACE1 and ACE2 activity has been implicated in the pathogenesis of respiratory diseases and could play a role in the severity of COVID-19. Functional ACE1/ACE2 gene polymorphisms have been associated with the risk of cardiovascular and pulmonary diseases, and could thus also contribute to the outcome of COVID-19. We studied 204 COVID-19 patients (137 non-severe and 67 severe-ICU cases) and 536 age-matched controls. The ACE1 insertion/deletion and ACE2 rs2285666 polymorphism were determined. Variables frequencies were compared between the groups by logistic regression. We also sequenced the ACE2 coding nucleotides in a group of patients. Severe COVID-19 was associated with hypertension male gender (p
Databáze: OpenAIRE
Externí odkaz: