Cytotoxicity of Postmodified Zeolitic Imidazolate Framework-90 (ZIF-90) Nanocrystals: Correlation between Functionality and Toxicity
| Autor: | Rong-Jie Chein, Jih Ru Hwu, Yi Hsin Liu, Jhe Wei Wu, Chia I. Yen, Fa Kuen Shieh, Kevin C.-W. Wu, Wei Shang Lo, Nianhan Ma, Renqiang Yang, Szu Mam Liu |
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| Rok vydání: | 2016 |
| Předmět: |
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Molecular Nanoparticle 02 engineering and technology 010402 general chemistry 01 natural sciences Aldehyde Catalysis chemistry.chemical_compound Imidazolate Organic chemistry Sulfhydryl Compounds Cytotoxicity Amination chemistry.chemical_classification Aldehydes Organic Chemistry Imidazoles General Chemistry 021001 nanoscience & nanotechnology Combinatorial chemistry 0104 chemical sciences chemistry Zeolites Thiol Nanoparticles Metal-organic framework 0210 nano-technology Drug carrier Zeolitic imidazolate framework |
| Zdroj: | Chemistry - A European Journal. 22:2925-2929 |
| ISSN: | 0947-6539 |
| DOI: | 10.1002/chem.201505005 |
| Popis: | Using a simple method, the aldehyde groups of zeolitic imidazolate framework-90 (ZIF-90) nanocrystals were converted into carboxyl, amino, and thiol groups, without affecting the integrity of the framework. Notably, for the first time, correlations between functionality and cytotoxicity are also demonstrated via in vitro cytotoxicity assays. The positive charged aminated-ZIF-90 presumably results in either perturbation of cell membrane, more efficient cell uptake, or both. Therefore, the half-maximal effective (EC50 ) concentration of aminated-ZIF-90 has a higher cytotoxicity of about 30 μg mL(-1) . |
| Databáze: | OpenAIRE |
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