IL-4 VNTR gene polymorphism in chronic polyarthritis. The rare allele is associated with protection against destruction
| Autor: | Gordon W. Duff, Edouard Vannier, Pierre Miossec, N. Buchs, F. S. Di Giovine, Tania Silvestri, Martine Chabaud |
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| Rok vydání: | 2000 |
| Předmět: |
Male
Genetic Linkage Sialoglycoproteins Arthritis Genetic determinism Arthritis Rheumatoid Rheumatology Gene Frequency Polymorphism (computer science) Reference Values medicine Humans Pharmacology (medical) Allele Alleles Polymorphism Genetic medicine.diagnostic_test business.industry Receptors IgE HLA-DR Antigens Middle Aged medicine.disease Receptors Interleukin-4 Radiography Interleukin 1 Receptor Antagonist Protein Solubility Tandem Repeat Sequences Erythrocyte sedimentation rate Rheumatoid arthritis Immunology Chronic Disease Polyarthritis Female Gene polymorphism Interleukin-4 business Biomarkers Interleukin-1 |
| Zdroj: | Rheumatology (Oxford, England). 39(10) |
| ISSN: | 1462-0324 |
| Popis: | Objective. To evaluate the occurrence of variants of the interleukin 4 (IL-4) and IL-4 receptor (IL-4R) genes in patients with rheumatoid arthritis (RA) and their possible contribution to joint destruction. Methods. Allelic frequencies for polymorphisms in the IL-4 [variable number of tandem repeat ( VNTR) polymorphism in intron 3] and IL-4 receptor a chain (transition at nucleotide 1902) genes were assessed in 335 RA patients and 104 controls. Clinical indices of disease activity, disability and joint destruction and plasma levels of IL-1b, IL-1Ra and sCD23 were assessed to evaluate a possible functional effect. Results. Carriage of the rare IL-4(2) allele was higher in patients with non-destructive RA (40%) than in those with destructive RA (22.3%; odds ratio = 1.9, 95% confidence interval 1.1–3.5, P = 0.0006) and in controls (26%, P = 0.002). Patients positive for this rare allele had significantly less joint destruction, assessed by the Larsen wrist index (P = 0.004) and a lower erythrocyte sedimentation rate (P = 0.04). A significantly higher carriage rate of IL-4(2) was seen in HLA-DR4/DR1− patients with non-destructive RA than in those with destructive RA. The IL-4 receptor polymorphism was not over-represented. Plasma levels of IL-1b, IL-1Ra and sCD23, known to be modified by IL-4, were not different in individuals having different alleles. Conclusion. This IL-4 VNTR gene polymorphism may be a protective factor for severe joint destruction in RA that could be used as a prognostic marker early in the course of the disease. K : Interleukin 4, Rheumatoid arthritis, Gene polymorphism, Destruction. |
| Databáze: | OpenAIRE |
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