Two outbreaks of influenza A (H3N2) in a Japanese nursing home in the winter of 1996-1997, with differing vaccine efficacy
| Autor: | Masaaki Arakawa, Kohei Kameyama, Katsumi Mizuta, Naoya Murayama, Hiroshi Suzuki, Kuniaki Nerome |
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| Rok vydání: | 1999 |
| Předmět: |
Male
Fever Influenza vaccine medicine.disease_cause General Biochemistry Genetics and Molecular Biology Disease Outbreaks Japan Influenza Human Influenza A virus medicine Live attenuated influenza vaccine Humans Prospective Studies Aged Aged 80 and over business.industry Influenza A Virus H3N2 Subtype virus diseases Outbreak General Medicine Hemagglutination Inhibition Tests Vaccine efficacy Virology Vaccination Immunization Influenza Vaccines Relative risk Female business |
| Zdroj: | The Tohoku journal of experimental medicine. 188(4) |
| ISSN: | 0040-8727 |
| Popis: | Sixty of 128 (46.9%) residents of a nursing home were immunized with two doses of the trivalent split influenza vaccine. They developed 7.4-11.5-fold antibody increases, with a 69-82% protection rate, presenting good immune response rates to the influenza vaccine. Two outbreaks of influenza A (H3N2) occurred. There were no significant antigenic differences among the vaccine strain and the strains isolated from both outbreaks in haemagglutination-inhibition tests, suggesting that the second might have been a reoccurrence. There were no residents who were infected in both outbreaks. The vaccine efficacy against clinical illness in the first outbreak of typical influenza-like-illness (ILI) was 51% (relative risk: 0.49), and the febrile period was reduced significantly by vaccination. In the second outbreak, however, in which all patients had atypical ILI with a high fever but not respiratory symptoms, vaccine efficacy was not apparent for unknown reason. |
| Databáze: | OpenAIRE |
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