The clinicopathological characteristic associations of long non-coding RNA gene H19 polymorphisms with uterine cervical cancer
| Autor: | Chun-Fang Hsu, Ming-Chao Huang, Huang-Pin Shen, Yi-Hung Sun, Soo-Cheen Ng, Shun-Fa Yang, Po-Hui Wang, Yueh-Chun Lee, Ying-Hsiang Chou |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Single-nucleotide polymorphism Cervical intraepithelial neoplasia Metastasis 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Parametrium Lymph node Cervical cancer lymph node metastasis business.industry clinicopathological characteristics Positive Pelvic Lymph Node Odds ratio medicine.disease 5 year survival 030104 developmental biology medicine.anatomical_structure long non-coding RNA gene H19 business uterine cervical cancer 030217 neurology & neurosurgery Research Paper |
| Zdroj: | Journal of Cancer |
| ISSN: | 1837-9664 |
| DOI: | 10.7150/jca.36707 |
| Popis: | The purposes of the current study were conducted to explore the relationships among long non-coding RNA gene H19 (LncRNA H19) polymorphisms and clinicopathological characteristics of uterine cervical cancer, and patient prognosis in Taiwan. Five genetic variants of LncRNA H19 rs3024270, rs2839698, rs3741219, rs2107425 and rs217727 were recruited from one hundred and thirty-four patients with invasive cancer, 101 with high-grade cervical intraepithelial neoplasia (CIN) of uterine cervix and 325 controls and their genetic distributions were determined. It indicated no associations of these LncRNA H19 genetic variants with development of cervical cancer. CC/CT in LncRNA H19 rs2839698 exhibited less risk to have pelvic lymph node metastasis [Odds ratio (OR): 0.19, 95% Confidence interval (CI):0.04-0.82, p=0.028)], as compared with TT. Meanwhile, cervical cancer patients with AA/AG in rs3741219 also had less risk to develop pelvic lymph node metastasis (OR: 0.17, 95% CI: 0.05-0.63, p=0.008), large tumor (OR: 0.17, 95% CI: 0.04-0.82, p=0.014) as well as parametrium (OR: 0.26, 95% CI: 0.07-0.95, p=0.045) and vagina invasion (OR: 0.25, 95% CI: 0.07-0.91, p=0.041, as compared to those with GG. However, only positive pelvic lymph node metastasis was related to worse recurrence-free survival and poor overall survival. Conclusively, it indicated no association of LncRNA H19 SNPs with cervical carcinogensis in Taiwanese women. Although genotypes TT in LncRNA H19 rs2839698 and GG in rs3741219 are related to some poor clinicopathological parameters of cervical cancer, only pelvic lymph node status could predict 5 year patient survival significantly. |
| Databáze: | OpenAIRE |
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