Lymphoepithelioma-like carcinoma of the bladder: three cases with clinicopathological and p53 protein expression study
| Autor: | Anabel Saez, Isabel Fernández, Alberto Pérez-Rosado, Rafael Guerreiro-Gonzalez, Fructuoso Garcia-Diez, Francisco Miguel Izquierdo-Garcia, Manuel Emilio Beneitez-Alvarez, Dimas Suárez-Vilela |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Male
Lymphoepithelioma-like carcinoma Pathology medicine.medical_specialty Urinary Bladder Population Biology medicine.disease_cause Polymerase Chain Reaction Disease-Free Survival Pathology and Forensic Medicine Antigen medicine Carcinoma Humans education Molecular Biology In Situ Hybridization Aged Lymphoepithelioma Aged 80 and over education.field_of_study Urinary bladder Epithelial Cells DNA Neoplasm Cell Biology General Medicine Genes p53 medicine.disease Epstein–Barr virus Treatment Outcome medicine.anatomical_structure Urinary Bladder Neoplasms Carcinoma Squamous Cell Immunohistochemistry Female Radiotherapy Adjuvant Tumor Suppressor Protein p53 T-Lymphocytes Cytotoxic |
| Zdroj: | Virchows Archiv. 444:420-425 |
| ISSN: | 1432-2307 0945-6317 |
| Popis: | Lymphoepithelioma-like carcinoma of the blad- der is an uncommon neoplasm, of which 49 cases have been described in the English literature, none of which has been studied for p53 protein expression. We studied three muscle-infiltrating cases of this tumor using immunohis- tochemical, in situ hybridization and polymerase chain reaction (PCR) methods. The three cases were positive for epithelial markers and negative for lymphoid antigens in the tumoral syncytial areas. The intensive infiltrate of small cells was negative for epithelial and positive for lymphoid markers. This population was mainly made up of cytotoxic T-lymphocytes, positive for TIA-1. p53 pro- tein was intensely positive in more than 90% of the epi- thelial component nuclei, being negative in the lymphoid cells. PCR study did not show mutations on p53. Both lymphocytes and epithelium were negative for Epstein- Barr virus markers, such as the latent membrane protein and EBER (Epstein-Barr-encoded RNA). The prognosis was very good after radiotherapy and chemotherapy treatment, preserving the bladder despite the muscle in- filtration. The presence of an intense cytotoxic T-lym- phocyte population may be related to this good prognosis. Both aspects, p53 protein status and T-lymphoid popula- tion, had never been studied before in bladder lympho- epithelioma-like carcinoma. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink