Paget’s disease of bone is not associated with common polymorphisms in interleukin-6, interleukin-8 and tumor necrosis factor alpha genes
Autor: | Judit García-Aparicio, Rogelio González-Sarmiento, Javier del Pino-Montes, Luis Corral-Gudino, Manuel Alonso-Garrido |
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Rok vydání: | 2010 |
Předmět: |
Male
Genotype Immunology information science Protein Data Bank (RCSB PDB) Single-nucleotide polymorphism Polymorphism Single Nucleotide Biochemistry medicine Humans Immunology and Allergy natural sciences Interleukin 8 Interleukin 6 Molecular Biology Alleles biology Interleukin-6 Tumor Necrosis Factor-alpha Interleukin-8 Interleukin Hematology Osteitis Deformans medicine.disease Paget's disease of bone health occupations biology.protein Female Tumor necrosis factor alpha |
Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
ISSN: | 1043-4666 |
Popis: | [Background]: Cytokines, specially interleukin (IL)-6, play an important role in the differentiation and activation of osteoclasts and might be involved in osteoblast stimulation in Paget’s disease of bone (PDB). [Objectives]: The aim of this study was to investigate the association of polymorphisms in IL-6, IL-8 and tumor necrosis factors-alpha (TNFA) genes among Spanish patients with PDB. [Methods]: We studied four single nucleotide polymorphisms (−174 G > C IL-6, −251 T > A IL-8, −238 G > A TNFA and −308 G > A TNFA) in 172 PDB patients and 150 healthy controls. Distribution of alleles and pro-inflammatory genotypes were studied for association with the presence of the disease and with clinical and laboratory data, as well as the response to bisphosphonate treatment in PDB patients. [Results]: We found no statistically significant association between genotype and allele distribution of any of the cytokines polymorphism studied and PDB. No association between the clinical and therapeutic characteristics of PDB and the investigated polymorphism were found. [Conclusions]: This study does not support the hypothesis that the analyzed IL6, IL8 and TNFA polymorphism are associated with PDB. This study was partially supported by a grant from the Junta de Castilla y León, Spain (HUS5/04). |
Databáze: | OpenAIRE |
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