Xenon Blocks Neuronal Injury Associated with Decompression
| Autor: | Jacques H. Abraini, Jean-Jacques Risso, Nicolas Vallée, Jean-Eric Blatteau, Kate Lambrechts, Cédric Meckler, Sebastien Demaistre, Hélène N. David |
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| Rok vydání: | 2015 |
| Předmět: |
Male
musculoskeletal diseases Time Factors Xenon Decompression Excitotoxicity chemistry.chemical_element medicine.disease_cause Neuroprotection Article Decompression sickness chemistry.chemical_compound Lactate dehydrogenase Animals Medicine In patient Multidisciplinary L-Lactate Dehydrogenase business.industry Brain Decompression Sickness medicine.disease Rats Disease Models Animal Neuroprotective Agents chemistry Anesthesia Nervous System Diseases business Ex vivo |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | Despite state-of-the-art hyperbaric oxygen (HBO) treatment, about 30% of patients suffering neurologic decompression sickness (DCS) exhibit incomplete recovery. Since the mechanisms of neurologic DCS involve ischemic processes which result in excitotoxicity, it is likely that HBO in combination with an anti-excitotoxic treatment would improve the outcome in patients being treated for DCS. Therefore, in the present study, we investigated the effect of the noble gas xenon in an ex vivo model of neurologic DCS. Xenon has been shown to provide neuroprotection in multiple models of acute ischemic insults. Fast decompression compared to slow decompression induced an increase in lactate dehydrogenase (LDH), a well-known marker of sub-lethal cell injury. Post-decompression administration of xenon blocked the increase in LDH release induced by fast decompression. These data suggest that xenon could be an efficient additional treatment to HBO for the treatment of neurologic DCS. |
| Databáze: | OpenAIRE |
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