AIDS-related cryptosporidial diarrhoea: an open study with roxithromycin
| Autor: | Suzane Silbert, G Schestatsky, R Mallman, D. Bem David, Eduardo Sprinz, S Barcellos |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Adult
Diarrhea Male Microbiology (medical) medicine.medical_specialty Abdominal pain medicine.medical_treatment Cryptosporidiosis Cryptosporidium Antiviral Agents Gastroenterology Internal medicine medicine Animals Humans Pharmacology (medical) Adverse effect Immunodeficiency Antibacterial agent Pharmacology Acquired Immunodeficiency Syndrome Roxithromycin Chemotherapy AIDS-Related Opportunistic Infections business.industry Middle Aged medicine.disease Anti-Bacterial Agents Surgery Infectious Diseases Concomitant Female medicine.symptom business medicine.drug |
| Zdroj: | Journal of Antimicrobial Chemotherapy. 41:85-91 |
| ISSN: | 1460-2091 0305-7453 |
| DOI: | 10.1093/jac/41.suppl_2.85 |
| Popis: | In immunocompromised patients, cryptosporidial diarrhoea is a debilitating and potentially life-threatening infection for which no effective specific therapy exists. In an uncontrolled study of 24 AIDS patients with diarrhoea exclusively due to Cryptosporidium spp., treatment with roxithromycin, 300 mg bd for 4 weeks, produced symptomatic improvement of diarrhoea in 79% of cases, with 50% of patients achieving complete response. The response rate was 100% in a subgroup of five patients with no previous or concomitant opportunistic infections. In complete responders, improvement was rapid, occurring within 3-5 days, and the duration of response was at least 6 months. Response did not appear to be correlated with the degree of immunodeficiency. The most limiting adverse effects were abdominal pain (two patients), elevated hepatic enzymes (two patients) and abdominal pain with elevated hepatic enzymes (one patient). Minor symptoms, such as gastrointestinal upset, occurred in nine patients. We conclude that roxithromycin is relatively well tolerated and effective against cryptosporidial diarrhoea in AIDS patients. Further studies to optimize dosing regimens are required. |
| Databáze: | OpenAIRE |
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