Host-microbe cross-talk in the lung microenvironment
| Autor: | Sabine Bartel, Philip M. Hansbro, Ian M. Adcock, Hermelijn H. Smits, Frank R. M. Stassen, Pieter S. Hiemstra, Robert P. Dickson, Ken R. Bracke, Reinoud Gosens, Susanne Krauss-Etschmann |
|---|---|
| Přispěvatelé: | Molecular Pharmacology, Groningen Research Institute for Asthma and COPD (GRIAC), Med Microbiol, Infect Dis & Infect Prev, RS: NUTRIM - R2 - Liver and digestive health |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Pulmonary and Respiratory Medicine
Lung Diseases medicine.medical_specialty Respiratory Tract Diseases Respiratory System Gut flora HAEMOPHILUS-INFLUENZAE OBSTRUCTIVE PULMONARY-DISEASE 03 medical and health sciences 0302 clinical medicine INTESTINAL MICROBIOTA Medicine and Health Sciences Medicine Humans 030212 general & internal medicine Microbiome Intensive care medicine Lung 11 Medical and Health Sciences ALLERGIC AIRWAY DISEASE Science & Technology CYSTIC-FIBROSIS biology business.industry IMMUNE-RESPONSES Microbiota OUTER-MEMBRANE VESICLES Respiratory disease GUT MICROBIOTA Human microbiome EPITHELIAL-CELLS biology.organism_classification medicine.disease Back to Basics Respiration Disorders medicine.anatomical_structure 030228 respiratory system 11 Medical and Health Sciences 1116 Medical Physiology Lung disease RESPIRATORY MICROBIOTA business Life Sciences & Biomedicine |
| Zdroj: | European Respiratory Journal, 56(2):1902320. EUROPEAN RESPIRATORY SOC JOURNALS LTD The European Respiratory Journal article-version (VoR) Version of Record European Respiratory Journal, 56(2). EUROPEAN RESPIRATORY SOC JOURNALS LTD EUROPEAN RESPIRATORY JOURNAL European Respiratory Journal, 56(2):1902320. European Respiratory Society |
| ISSN: | 0903-1936 1399-3003 |
| Popis: | Chronic respiratory diseases are highly prevalent worldwide and will continue to rise in the foreseeable future. Despite intensive efforts over recent decades, the development of novel and effective therapeutic approaches has been slow. However, there is new and increasing evidence that communities of micro-organisms in our body, the human microbiome, are crucially involved in the development and progression of chronic respiratory diseases. Understanding the detailed mechanisms underlying this cross-talk between host and microbiota is critical for development of microbiome- or host-targeted therapeutics and prevention strategies. Here we review and discuss the most recent knowledge on the continuous reciprocal interaction between the host and microbes in health and respiratory disease. Furthermore, we highlight promising developments in microbiome-based therapies and discuss the need to employ more holistic approaches of restoring both the pulmonary niche and the microbial community. The reciprocal interaction between microbes and host in the lung is increasingly recognised as an important determinant of health. The complexity of this cross-talk needs to be taken into account when studying diseases and developing future new therapies. https://bit.ly/2VKYUfT |
| Databáze: | OpenAIRE |
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