Glutathione infusion potentiates glucose-induced insulin secretion in aged patients with impaired glucose tolerance
| Autor: | Felice D'Onofrio, Giuseppe Paolisso, Tesauro P, Dario Giugliano, Michele Varricchio, Antonio Gambardella, Gennaro Pizza |
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| Přispěvatelé: | Paolisso, Giuseppe, Giugliano, Dario, Pizza, G, Gambardella, Antonio, Tesauro, P, Varricchio, M, D'Onofrio, F. |
| Předmět: |
Blood Glucose
medicine.medical_specialty Time Factors Endocrinology Diabetes and Metabolism medicine.medical_treatment Impaired glucose tolerance chemistry.chemical_compound Diabetes mellitus Internal medicine Insulin Secretion Internal Medicine Medicine Humans Insulin Pancreatic hormone Aged Advanced and Specialized Nursing Glucose tolerance test medicine.diagnostic_test business.industry Glutathione Glucose clamp technique Glucose Tolerance Test medicine.disease Glucagon Endocrinology Basal (medicine) chemistry Hyperglycemia Glucose Clamp Technique business |
| Zdroj: | Scopus-Elsevier |
| Popis: | Objective –To evaluate the effect of glutathione infusion on β-cell response to glucose in elderly people with impaired glucose tolerance (IGT). Research Desigh and Methods –Ten patients with normal glucose tol-erance and 10 patients with IGT were matched for age (mean ± SE, 72.1 ± 2.8 vs. 71.0 ± 3.4 yr), body mass index (23.1 ± 1.1 vs. 22 ± 2.1 kg/m2), and sex (6/4 vs. 5/5, men/women) underwent glutathione infusion (10 mg/min) under basal conditions and during 75-g oral glucose tolerance tests and intravenous glucose tolerance tests (0.33 g.kg body wt−1.3 min−1). Patients with IGT were also submitted to euglycemic-hyperinsulemic and hyperglycemic glucose clamps. Results –In subjects with normal glucose tolerance, glutathione infusion failed to affect β-cell response to glucose. In contrast, glutathione significantly potentiated glucose-induced insulin secretion in patients with IGT. Furthermore, in the latter group studied by hyperglycemic clamps, glutathione infusion significantly potentiated the beta-cell response to glucose when plasma glucose levels varied between 10 and 15 mM. This effect disappeared at plasma glucose levels Conclusios –Glutathione infusion enhances insulin secretion in elderly people with IGT. |
| Databáze: | OpenAIRE |
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