Hemorrhage Control of Liver Injury by Short Electrical Pulses
| Autor: | Guy Malki, Eid Adawi, Arnon Afek, Elon Glassberg, Michael Zagetzki, Ofer Barnea, Yossi Mandel |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Critical Care and Emergency Medicine Medical Physics lcsh:Medicine Blood volume Abdominal cavity Biophysics Simulations Rats Sprague-Dawley Engineering lcsh:Science Cause of death Liver injury Multidisciplinary Physics Liver Diseases Animal Models Thrombosis medicine.anatomical_structure Liver Anesthesia Medicine Hemorrhage control Rabbits medicine.symptom Research Article Resuscitation Trauma Surgery Finite Element Analysis Biomedical Engineering Biophysics Bioengineering Electric Stimulation Therapy Hemorrhage Gastroenterology and Hepatology Medical Devices Model Organisms medicine Animals Humans Biology Hemostatic Techniques business.industry lcsh:R Hyperthermia Induced medicine.disease Rats Disease Models Animal Rat lcsh:Q Surgery Intravascular thrombosis business Vasoconstriction |
| Zdroj: | PLoS ONE PLoS ONE, Vol 8, Iss 1, p e49852 (2013) |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0049852 |
| Popis: | Trauma is a leading cause of death among young individuals globally and uncontrolled hemorrhage is the leading cause of preventable death. Controlling hemorrhage from a solid organ is often very challenging in military as well as civilian setting. Recent studies demonstrated reversible vasoconstriction and irreversible thrombosis following application of microseconds-long electrical pulses. The current paper describes for the first time reduction in bleeding from the injured liver in rat and rabbit model in-vivo. We applied short (25 and 50 µs) electrical pulses of 1250 V/cm to rats and rabbit liver following induction of standardized penetrating injury and measured the amount of bleeding into the abdominal cavity one hour post injury. We found a 60 and 36 percent reduction in blood volume in rats treated by 25 µs and 50 µs, respectively (P |
| Databáze: | OpenAIRE |
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