Immunopathological characteristics of coronavirus disease 2019 cases in Guangzhou, China
Autor: | Xilong Deng, Yaling Shi, Jingyi Ou, Jide Huang, Xing Chen, Mingkai Tan, Yanxia Liu |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Male
0301 basic medicine Neutrophils T-Lymphocytes Severity of Illness Index T-Lymphocytes Regulatory SARS‐CoV‐2 0302 clinical medicine Immunology and Allergy Medicine Lymphocytes Respiratory system B-Lymphocytes Immune cells Interleukin-10 Killer Cells Natural Editorial Cytokines Female Original Article medicine.symptom Coronavirus Infections Cell type China Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Immunology Pneumonia Viral Inflammation 03 medical and health sciences Betacoronavirus Immune system COVID‐19 Severity of illness Humans Pandemics Aged business.industry Interleukin-6 SARS-CoV-2 Therapeutic effect COVID-19 Original Articles Coronavirus 030104 developmental biology business CD8 030215 immunology |
Zdroj: | Immunology |
ISSN: | 1365-2567 0019-2805 |
Popis: | SummaryCoronavirus disease 2019 (COVID-19) is a respiratory disorder caused by the highly contagious SARS-CoV-2. The immunopathological characteristics of COVID-19 patients, either systemic or local, have not been thoroughly studied. In the present study, we analyzed both the changes in the cellularity of various immune cell types as well as cytokines important for immune reactions and inflammation. Our data indicate that patients with severe COVID-19 exhibited an overall decline of lymphocytes including CD4+ and CD8+ T cells, B cells, and NK cells. The number of immunosuppressive regulatory T cells was moderately increased in patients with mild COVID-19. IL-2, IL-6, and IL-10 were remarkably up-regulated in patients with severe COVID-19. The levels of IL-2 and IL-6 relative to the length of hospital stay underwent a similar “rise-decline”pattern, probably reflecting the therapeutic effect. In conclusion, our study shows that the comprehensive decrease of lymphocytes, and the elevation of IL-2 and IL-6 are reliable indicators of severe COVID-19. |
Databáze: | OpenAIRE |
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