Roadblocks to translational advances on metastasis research
| Autor: | David Lyden, Zena Werb, Patricia S. Steeg, Thomas Brabletz |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Pathology
medicine.medical_specialty Epithelial-Mesenchymal Transition Biomedical Immunology Cancer therapy Patient advocacy Medical and Health Sciences General Biochemistry Genetics and Molecular Biology Article Metastasis Translational Research Biomedical Neoplasms Drug Discovery Translational Research Medicine Humans Neoplasm Metastasis Translational Medical Research Cancer business.industry General Medicine medicine.disease General partnership Neoplastic Stem Cells Engineering ethics business |
| Zdroj: | Nature medicine, vol 19, iss 9 |
| Popis: | Promising advances in cancer therapy stemming from an increasing understanding of the molecular and genetic underpinnings of the tumorigenic process have been fueled by a strong, determined scientific community, influential patient advocacy groups and committed funding bodies. Despite these efforts, the development of effective drugs to prevent systemic dissemination of cancer cells or to eliminate overt metastasis in secondary organs remains a challenge to both researchers and physicians. In an attempt to tackle the most relevant and timely translational issues, a meeting held in 2012 as a result of a successful partnership between the Volkswagen Foundation and Nature Medicine brought together a group of metastasis research experts to identify the most important hurdles and help create a framework for potential clinical and translational strategies. |
| Databáze: | OpenAIRE |
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