What can platinum offer yet in the treatment of PS2 NSCLC patients? A systematic review and meta-analysis
| Autor: | Cosimo Lequaglie, Antonio Russo, Eugenio Fiorentino, Daniele Santini, Patrick Pauwels, Massimo Cajozzo, Francesco Passiglia, Sergio Rizzo, Giuseppe Bronte, Ignacio Gil-Bazo, Christian Rolfo, Jan P. van Meerbeeck |
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| Přispěvatelé: | Bronte, G., Rolfo, C., Passiglia, F., Rizzo, S., Gil-Bazo, I., Fiorentino, E., Cajozzo, M., Van Meerbeeck, J., Lequaglie, C., Santini, D., Pauwels, P., Russo, A |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Oncology
medicine.medical_specialty Lung Neoplasms Phase iii trials Settore MED/06 - Oncologia Medica medicine.medical_treatment Population Settore MED/21 - Chirurgia Toracica NSCLC law.invention Single agent Overall response rate Randomized controlled trial Performance statu Chemotherapy Performance status Platinum Doublet law Carcinoma Non-Small-Cell Lung Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Intensive care medicine education Randomized Controlled Trials as Topic education.field_of_study business.industry Hematology Survival Rate Meta-analysis Non small cell Human medicine business |
| Zdroj: | Critical reviews in oncology, hematology |
| ISSN: | 1040-8428 |
| Popis: | Background: Randomized phase III trials showed interesting, but conflicting results, regarding the treatment of NSCLC, PS2 population. This meta-analysis aims to review all randomized trials comparing platinum-based doublets and single-agents in NSCLC PS2 patients. Materials and methods: Data from all published randomized trials, comparing efficacy and safety of platinum-based doublets to single agents in untreated NSCLC, PS2 patients, were collected. Pooled ORs were calculated for the 1-year Survival-Rate (ly-SR), Overall Response Rate (ORR), and grade 3-4 (G3-4) hematologic toxicities. Results: Six eligible trials (741 patients) were selected. Pooled analysis showed a significant improvement in ORR (OR: 3.243; 95% CI: 1.883-5.583) and ly-SR (OR: 1.743; 95% CI: 1.203-2.525) in favor of platinum-based doublets. 03-4 hematological toxicities were also more frequent in this group. Conclusion: This meta-analysis suggests that platinum-combination regimens are superior to singleagent both in terms of ORR and survival-rate with increase of severe hematological toxicities. (C) 2015 Elsevier Ireland Ltd. All rights reserved. |
| Databáze: | OpenAIRE |
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