Autor: |
Pankaj Tailor, Keith C.K. Lau, Franz J. Zemp, Dae-Sun Kim, Andrea Rakic, Robin M. Yates, Chris Gafuik, Victor Naumenko, Chunfen Zhang, Saif Sikdar, Dale R. Balce, Matthias Ernst, Craig N. Jenne, Douglas J. Mahoney, Ben W. Ewanchuk, Himika Dastidar, Jahanara Rajwani |
Jazyk: |
angličtina |
Rok vydání: |
2018 |
Předmět: |
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Zdroj: |
Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018) Nature Communications |
ISSN: |
2041-1723 |
Popis: |
Second mitochondrial activator of caspase (Smac)-mimetic compounds and oncolytic viruses were developed to kill cancer cells directly. However, Smac-mimetic compound and oncolytic virus therapies also modulate host immune responses in ways we hypothesized would complement one another in promoting anticancer T-cell immunity. We show that Smac-mimetic compound and oncolytic virus therapies synergize in driving CD8 |
Databáze: |
OpenAIRE |
Externí odkaz: |
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