Effect of salvianolic acid A, a depside from roots of Salvia miltiorrhiza, on gastric H+,K(+)-ATPase
| Autor: | Haruko Kijima, Susumu Otomo, Shigeru Murakami, Makoto Muramatsu, L N Li, Yoshihiko Isobe, Hironaka Aihara, C B Ai |
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| Rok vydání: | 1990 |
| Předmět: |
Male
Stereochemistry Swine ATPase Pharmaceutical Science Salvia Pharmacognosy Pharmacology In Vitro Techniques H(+)-K(+)-Exchanging ATPase Salvia miltiorrhiza Depsides Analytical Chemistry Gastric Acid chemistry.chemical_compound Caffeic Acids Drug Discovery Hydroxybenzoates Animals Stomach Ulcer IC50 Adenosine Triphosphatases biology Molecular Structure Organic Chemistry Biological activity Rats Inbred Strains biology.organism_classification Anti-Ulcer Agents Rats Disease Models Animal Kinetics Complementary and alternative medicine chemistry Gastric Mucosa biology.protein Lactates Molecular Medicine Depside Drugs Chinese Herbal |
| Zdroj: | Planta medica. 56(4) |
| ISSN: | 0032-0943 |
| Popis: | Salvianolic acid A, a depside from the roots of Salvia miltiorrhiza, inhibited pig gastric H+,K(+)-ATPase and pNPPase with 50% inhibition values (IC50) of 5.2 x 10(-7) M and 1.7 x 10(-6) M, respectively. Kinetic studies revealed that the inhibition patterns induced by salvianolic acid A were competitive with respect to ATP and noncompetitive with respect to K+. Salvianolic acid A (25 mg/kg, i.p.) significantly inhibited acid secretion in pylorus-ligated rats. At the same dose it also showed a significant reduction in the formation of gastric lesion induced by water immersion and restraint stress. These results suggest that salvianolic acid A shows antisecretory and antiulcer activity by inhibiting the gastric H+,K(+)-ATPase. |
| Databáze: | OpenAIRE |
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