Mixed germ cell-sex cord stromal tumour of the testis and ovary: comparison and contrast
| Autor: | Lawrence M. Roth, Liang Cheng |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Genetic Markers
Male 0301 basic medicine endocrine system medicine.medical_specialty Pathology Cord Gonad Stromal tumours Ovary Biology Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Testicular Neoplasms Molecular genetics Testis Biomarkers Tumor medicine Humans Sex Cord-Gonadal Stromal Tumors Epigenetics Pathology Molecular Ovarian Neoplasms Malignant Germ Cell Neoplasm Neoplasms Germ Cell and Embryonal Germ Cells 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Female Mixed germ cell-sex cord-stromal tumour |
| Zdroj: | Pathology. 53:166-169 |
| ISSN: | 0031-3025 |
| DOI: | 10.1016/j.pathol.2020.10.008 |
| Popis: | Mixed germ cell-sex cord stromal tumours (MGC-SCSTs) of the testis and ovary differ significantly in their histological appearance, clinical behaviour, and molecular genetics. Until recently, the germ cells of testicular MGC-SCST were considered to be invariably histologically bland, whereas those from neoplasms that arise in the ovary have histological features characteristic of premalignancy. However, a recent histological and molecular genetic study demonstrated histological abnormalities and multiple chromosomal losses and gains in a small subset of testicular cases, thus providing the first evidence that testicular MGC-SCSTs can exceptionally show histological and molecular abnormalities. All cases of testicular MGC-SCST reported to date have been clinically benign, whereas ovarian examples are sometimes the precursor of a malignant germ cell neoplasm that can be clinically aggressive. Both genetic and epigenetic influences likely account for dissimilarities in these uncommon gonadal neoplasms. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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