Evidence of differential control of FSH and LH responses to GnRH by ovarian steroids in the luteal phase of the cycle
| Autor: | Ioannis E. Messinis, K. Seferiadis, S. Milingos, Iordanis Mademtzis, G. Kollios, Elias Alexandris |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
endocrine system medicine.medical_specialty Estradiol/blood/*pharmacology medicine.drug_class Ovariectomy Luteal Phase/*metabolism Gonadotropin-releasing hormone Luteal phase Luteal Phase Hysterectomy Gonadotropin-Releasing Hormone Follicle-stimulating hormone Internal medicine Follicular phase Medicine Humans Luteinizing Hormone/blood/*secretion Postoperative Period Follicle Stimulating Hormone/blood/*secretion Progesterone Estradiol business.industry Fertility Agents Female/*pharmacology Rehabilitation Obstetrics and Gynecology Fertility Agents Female Luteinizing Hormone Middle Aged Gonadotropin secretion Gonadotropin-Releasing Hormone/*pharmacology Endocrinology Reproductive Medicine Estrogen Female Gonadotropin Progesterone/*pharmacology Follicle Stimulating Hormone business Luteinizing hormone hormones hormone substitutes and hormone antagonists |
| Zdroj: | Human reproduction (Oxford, England). 17(2) |
| ISSN: | 0268-1161 |
| Popis: | BACKGROUND: It is known that during the follicular phase of the cycle, estradiol sensitizes the pituitary to GnRH. The aim of this study was to determine the role of ovarian steroids in the control of GnRH-induced gonadotrophin secretion in the luteal phase of the cycle. METHODS: Eighteen normally cycling women were studied during the week following bilateral ovariectomy plus hysterectomy performed in early to mid-luteal phase. Six of the women received no hormonal treatment post-operatively (group 1, control), six received estradiol through skin patches (group 2) and the remaining six received estradiol plus progesterone (group 3). In all women the response at 30 min of LH (deltadeltaLH) and FSH (deltadeltaFSH) to GnRH (10 microg i.v.) was investigated on a daily basis. RESULTS: In group 1, serum FSH, LH and deltadeltaFSH values increased progressively following ovariectomy, while in groups 2 and 3 this increase was postponed or abolished. In contrast to deltadeltaFSH, deltadeltaLH values showed the same pattern of changes in all three groups with a significant decline up to post-operative day 4 and a gradual increase thereafter. CONCLUSIONS: These results demonstrate, for the first time, that in the early to mid-luteal phase of the cycle, estradiol and progesterone participate in the control of GnRH-induced FSH, but not LH, secretion. It is possible that in the luteal phase, the response of LH to GnRH is partly regulated by gonadotrophin surge attenuating factor. Hum Reprod |
| Databáze: | OpenAIRE |
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