Combination of structural MRI, functional MRI and brain PET-CT provide more diagnostic and prognostic value in patients of cerebellar ataxia associated with anti-Tr/DNER: a case report

Autor:	Dong Zhou, Sisi Shen, Ruiyi Yang, Ming Zhou, Jin-Mei Li, Wenyu Liu
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Adult medicine.medical_specialty Cerebellum Neurology Cerebellar Ataxia Precuneus Nerve Tissue Proteins Receptors Cell Surface Positron Emission Tomography Computed Tomography medicine Humans RC346-429 PET-CT Cerebellar ataxia business.industry Brain General Medicine Prognosis Magnetic Resonance Imaging medicine.anatomical_structure Frontal lobe Posterior cingulate Child Preschool Cerebellar vermis Female Neurology (clinical) Radiology Neurology. Diseases of the nervous system medicine.symptom business
Zdroj:	BMC Neurology, Vol 21, Iss 1, Pp 1-6 (2021)
ISSN:	1471-2377
Popis:	Background Brain magnetic resonance imaging (MRI) rarely reveals structural changes in patients with suspected anti-Tr/DNER encephalitis and thus provides very limited information. Here, we combined structural MRI, functional MRI, and positron emission tomography-computed tomography (PET-CT) findings to characterize this rare disorder in a patient. Case presentation A 43-year-old woman presented with progressive cerebellar ataxia, memory impairment, anxiety, and depression. Anti-Tr antibodies were detected in both her serum (1:10) and cerebrospinal fluid (1:10). A diagnosis of anti-Tr-positive autoimmune cerebellar ataxia was established. The patient’s symptoms were worse, but her brain MRI was normal. Meanwhile, voxel-based morphometry analysis showed bilateral reduced cerebellar volume, especially in the posterior lobe and uvula of the cerebellum and the middle of the left temporal lobe compared with 6 sex- and age-matched healthy subjects (6 females, 43 ± 2 years; p p Conclusions A combination of structural MRI, functional MRI, and brain PET-CT has higher diagnostic and prognostic value than conventional MRI in patients with suspected anti-Tr/DNER encephalitis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd0fdb8c2bf32905c826fa3be2b897d4 https://doaj.org/article/f60a9ac4f7334b38b125bb2528e5d173 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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