Cisplatin induced acute mesenteric ischaemia: A case report and review of the literature
| Autor: | Lauren Kennedy, Shivun Khosla, Yasser Abdulaal |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Acute mesenteric ischaemia CTA computed tomography angiogram TTE transthoracic echocardiogram AMAE acute mesenteric arterial embolism Gastroenterology Article Pathogenesis 03 medical and health sciences 0302 clinical medicine MDT multidisciplinary meeting Internal medicine Case report medicine AMAT acute mesenteric arterial thrombosis Cisplatin business.industry Vascular disease Head and neck cancer SMA superior mesenteric artery Arterial thrombosis Cancer medicine.disease Thrombosis LMWH low molecular weight heparin Venous thrombosis 030220 oncology & carcinogenesis UHI unfractionated heparin infusion Surgery ECG electrocardiogram Complication business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | International Journal of Surgery Case Reports |
| ISSN: | 2210-2612 |
| Popis: | Highlights • Arterial thrombosis occurs in 2% of patients having Cisplatin-based chemotherapy. • There is only one previous report detailing mesenteric ischaemia secondary to cisplatin. • The mechanism relating to the development of arterial thrombosis is not understood. • Benefit of prophylactic parenteral anticoagulation during cisplatin chemotherapy is unknown. Introduction Cisplatin is a platinum-based chemotherapeutic agent, widely used in cancer therapies for numerous solid tumours. It is becoming more recognised that a potentially life-threatening complication of cisplatin is accelerated arterial and venous thrombosis. Presentation of case We describe a case of a 62 year-old with no risk factors for vascular disease who presented with thromboembolic acute mesenteric ischaemia of the small bowel during treatment with cisplatin for head and neck cancer. Discussion We review the literature on the incidence and pathogenesis of cisplatin induced arterial thrombosis and discuss current treatment options of acute mesenteric ischaemia detailing our management of this case. Conclusion Cisplatin increases the risk of arterial thrombosis and this case report details acute mesenteric ischaemia secondary to its use. We hope to raise clinician awareness of this sequelae which can occur even in patients in the absence of other identifiable risk factors. |
| Databáze: | OpenAIRE |
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