Could Primary Hyperparathyroidism-Related Hypercalcemia Induce Hypercalcitoninemia?
| Autor: | Jf Henry, N. Morlet-Barla, F. Sebag, P Niccoli, F. Roux, Bernard Conte-Devolx |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Calcitonin Male medicine.medical_specialty endocrine system diseases Endocrinology Diabetes and Metabolism Multiple Endocrine Neoplasia Type 2a Gastroenterology Parathyroid Glands Endocrinology Internal medicine medicine Humans Aged Aged 80 and over business.industry Middle Aged Hyperparathyroidism Primary medicine.disease Pediatrics Perinatology and Child Health Hypercalcemia Calcium Female business Primary hyperparathyroidism |
| Zdroj: | Hormone Research in Paediatrics. 73:372-375 |
| ISSN: | 1663-2826 1663-2818 |
| DOI: | 10.1159/000308170 |
| Popis: | Aims: To determine if primary hyperparathyroidism (pHPT) per se may be responsible of hypercalcitoninemia. pHPT induces chronic hypercalcemia that should be expected to be a potential stimulatory pathway of calcitonin (CT) secretion and to cause hypercalcitoninemia. Method: We studied relationships between CT and pHPT-related chronic hypercalcemia in 122 patients aged 25–83 years who underwent parathyroid surgery. CT, calcium and PTH plasma levels were measured in all patients preoperatively. CT was measured by a current immunometric assay specific of mature CT monomer. Results: Of our 122 patients with pHPT-related hypercalcemia, 120 (98.4%) had normal CT values of less than 10 pg/ml and two (1.6%) exhibited a mildly increased CT above 10 pg/ml (11 and 12 pg/ml, respectively). We evidenced no relationship between CT and calcium level or PTH level. Conclusions: Chronic pHPT-related hypercalcemia per se does not cause hypercalcitoninemia. The finding of pHPT concomitant with high CT levels should raise suspicion of multiple endocrine neoplasia type 2A. |
| Databáze: | OpenAIRE |
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