Sequence, Structure, and Chromosomal Mapping of the MouseLgals6 Gene, Encoding Galectin-6
| Autor: | Robert E. Atchison, Samuel H. Barondes, Aldons J. Lusis, Michael A. Gitt, Hakon Leffler, Yu-Rong Xia |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Galectins
Galectin 4 Molecular Sequence Data Biology Biochemistry Mice Exon Centimorgan Apolipoproteins E Lectins otorhinolaryngologic diseases Animals Coding region Cloning Molecular Promoter Regions Genetic Molecular Biology Gene Repetitive Sequences Nucleic Acid Synteny Galectin Genetics Base Sequence Intron Chromosome Mapping Promoter Exons Cell Biology Introns Blotting Southern Hemagglutinins Multigene Family Digestive System |
| Zdroj: | Journal of Biological Chemistry. 273:2961-2970 |
| ISSN: | 0021-9258 2954-2960 |
| Popis: | In the accompanying paper (Gitt, M. A., Colnot, C., Poirier, F., and Barondes, S. H., and Leffler, H. (1998) J. Biol. Chem. 273, 2954-2960), we reported that mouse gastrointestinal tract specifically expresses two closely related galectins, galectins-4 and -6, each with two carbohydrate recognition domains in the same peptide. Here, we report the isolation, characterization, and chromosomal mapping of the complete mouse Lgals6 gene, which encodes galectin-6, and of a fragment of a distinct gene, Lgals4, which encodes galectin-4. The coding sequence of galectin-6 is specified by eight exons. The upstream region contains two putative promoters. Both Lgals6 and the closely related Lgals4 are clustered together about 3.2 centimorgans proximal to the apoE gene on mouse chromosome 7. The syntenic human region is 19q13.1-13.3. |
| Databáze: | OpenAIRE |
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