Genetic variants within micro RNA ‐binding site of RAD51B are associated with risk of cervical cancer in Chinese women

Autor:	Hongbin Shen, Yin Yin, Lihua Wang, Ni Li, Hongxia Ma, Meiqun Jia, Wen Zhou, Jing Zhou, Zhibin Hu, Dong Hang
Rok vydání:	2016
Předmět:	genetic variant Adult Risk 0301 basic medicine China Cancer Research Linkage disequilibrium Genotype Uterine Cervical Neoplasms Biology Bioinformatics Lower risk Polymorphism Single Nucleotide Linkage Disequilibrium homologous recombinational repair 03 medical and health sciences Asian People miRNA‐binding site medicine Humans Genetic Predisposition to Disease Radiology Nuclear Medicine and imaging RNA Messenger Allele Homologous Recombination 3' Untranslated Regions Alleles Original Research Aged Neoplasm Staging Cervical cancer RAD51B Binding Sites Haplotype Case-control study Genetic Variation Cancer Middle Aged medicine.disease DNA-Binding Proteins MicroRNAs 030104 developmental biology Oncology Case-Control Studies Female Cancer Prevention
Zdroj:	Cancer Medicine
ISSN:	2045-7634
DOI:	10.1002/cam4.797
Popis:	RAD51B plays a central role in homologous recombinational repair (HRR) of DNA double‐strand breaks (DSBs), which is important to prevent genomic instability, a hallmark of cancer. Recent studies suggested that common genetic variants of RAD51B may contribute to cancer susceptibility. In this study, we aimed to investigate whether potentially functional variants within miRNA‐binding sites of RAD51B are associated with risk of cervical cancer. A total of 1486 cervical cancer patients and 1536 cancer‐free controls were enrolled, and two genetic variants, rs963917 (A > G) and rs963918 (T > C), were genotyped in all participants. Using multivariate logistic regression analyses, we found that G allele of rs963917 conferred lower risk of cervical cancer compared to A allele (adjusted OR = 0.89, 95% CI = 0.80–0.99, P = 0.039). Similarly, rs963918 allele C was associated with a decreased risk for cervical cancer compared with allele T (adjusted OR = 0.84, 95% CI = 0.74–0.94, P = 0.004). Haplotype analyses showed that haplotype GC was also correlated with lower risk (OR = 0.83, 95% CI = 0.73–0.95, P = 0.005) compared with the most common haplotype AT. In summary, our study suggested that miRNA‐binding site genetic variants of RAD51B may modify the susceptibility to cervical cancer, which is important to identify individuals with differential risk for this malignancy and to improve the effectiveness of preventive intervention.
Databáze:	OpenAIRE
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